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Product Features

Low-volume and high-frequency sampling

Monitoring of multiple bioprocesses with high-frequency and fully automated sampling around the clock
Precise sample preparation

Significant and reliable data with Swiss precision technology
Membrane filtration

Consistent cell removal and maximum sample yield with high cell densities
Integration in Lucullus PIMS

From planning to evaluation: a unique solution from a single provider

Specification

SETUPS	Standard Setup	Advanced Setup
Multiplexer Modules	max 3	max 4
Reactors	max 12	max 16
sample path	Predefined sample path for each sample	Individual sample path for each sample in one process
Analyzer	1 HPLC and 1 cell analyzer	1 HPLC and up to 4 other analyzers (cell analyzer, biochemical analyzer etc.)

Sample processing	Duration min	Frequency h^-1	day^-1
Direct transfer	6'	10 h^-1	240 day^-1
Sampling + Filtration	10'	6 h^-1	144 day^-1
Sampling + Dilution	12'	5 h^-1	120 day^-1
Sampling + Dilution + Filtration	15'	4 h^-1	96 day^-1

Application

On-line analytics

The samples are automatically transferred to various directly coupled analytical devices. Analysis is started trough re-mote control and results are collected from our software Lucullus PIMS. Cell-containing samples are passed to cell analyzers or flow cytometers. Filtrated samples are directly injected in an HPLC or transferred to enzymatic bio analyzers.

Sample storage

Samples are collected and stored in cooled conditions in the Sample Collector. The size of the Sample Collector can be adapted to specific needs based on different volumes, numbers and types of vials.It performs additional liquid handling steps, if needed. Each vial is labeled with a unique barcode and sample ID for distinctive identification in subsequent analytics.

Sample processing

With the Dilution Module, biomass-containing samples are precisely diluted over a wide range. The simultaneous addition of reagents is used to perform protein precipitation, product extraction or staining reactions. The biomass-containing samples are filtrated with a unique Filtration Module with maximum sample yield. Cross-contamination is prevented by using a new filter section for each sample. The variety of available filter membranes allows to meet specific requirements, regarding cell-densi

Sampling

Biomass-containing samples are drawn automatically from stainless steel and benchtop glass bioreactors maintaining their sterility. Volumes up to 2 ml are drawn with minimum sample loss. Using Multiplexer Modules, up to 16 bioreactors or downstream devices are coupled independently, each connected with a sample line of up to 10 m length. The sampling frequency lies between 6 and 15 minutes only, depending on sample processing steps.